| Registro completo |
| Provedor de dados: |
BJMBR
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| País: |
Brazil
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| Título: |
An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice
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| Autores: |
Magro,D.A.C.
Hohmann,M.S.N.
Mizokami,S.S.
Cunha,T.M.
Alves-Filho,J.C.
Casagrande,R.
Ferreira,S.H.
Liew,F.Y.
Cunha,F.Q.
Verri Jr,W.A.
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| Data: |
2013-07-01
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| Ano: |
2013
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| Palavras-chave: |
Interleukin-33
ST2
Pain
Nociception
Inflammation
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| Resumo: |
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present study asked whether IL-33/ST2 signaling is relevant to overt pain-like behaviors in mice. Acetic acid and phenyl-p-benzoquinone induced significant writhing responses in wild-type (WT) mice; this overt nociceptive behavior was reduced in ST2-deficient mice. In an antigen-challenge model, ST2-deficient immunized mice had reduced induced flinch and licking overt pain-like behaviors. In the formalin test, ST2-deficient mice also presented reduced flinch and licking responses, compared with WT mice. Naive WT and ST2-deficient mice presented similar responses in the rota-rod, hot plate, and electronic von Frey tests, indicating no impairment of motor function or alteration in basal nociceptive responses. The results demonstrate that IL-33/ST2 signaling is important in the development of overt pain-like behaviors.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000700601
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| Editor: |
Associação Brasileira de Divulgação Científica
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| Relação: |
10.1590/1414-431X20132894
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Medical and Biological Research v.46 n.7 2013
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| Direitos: |
info:eu-repo/semantics/openAccess
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